Characterising Mechanisms That Underpin Drug Tolerance and Treatment Resistance in Colorectal Cancer Metastases.

Carbonic Anhydrase-IX Is a Specific and Sensitive Theragnostic Target for Imaging and Radioimmunotherapy in Metastatic Colorectal Cancer

D Swaroop, J Smith, J Van Zuykelom, A Noor, RA Wagner, T Vu, S Lee, AG Heriot, B Loveday, K Waldeck, PD Roselt, B Blyth, PS Donnelly, F Hollande

2026-01-01

Background and Aims: Over 40% of colorectal cancer (CRC) patients develop metastatic disease. Their survival outlook is very low, ..

A new natural killer cell-specific gene signature predicting recurrence in colorectal cancer patients

C Shembrey, M Foroutan, F Hollande

2023-01-06

The protective role of Natural Killer (NK) cell tumour immunosurveillance has long been recognised in colorectal cancer (CRC). How..

Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin

J Berthelet, M Foroutan, DD Bhuva, HJ Whitfield, F El-Saafin, J Cursons, A Serrano, M Merdas, E Lim, E Charafe-Jauffret, C Ginestier, M Ernst, F Hollande, RL Anderson, B Pal, B Yeo, MJ Davis, D Merino

2022-05-01

The development of therapies that target specific disease subtypes has dramatically improved outcomes for patients with breast can..

Longitudinal Monitoring of Intra-Tumoural Heterogeneity Using Optical Barcoding of Patient-Derived Colorectal Tumour Models

C Shembrey, J Smith, M Grandin, N Williams, HJ Cho, C Mølck, C Behrenbruch, BNJ Thomson, AG Heriot, D Merino, F Hollande

2022-02-01

Geno-and phenotypic heterogeneity amongst cancer cell subpopulations are established drivers of treatment resistance and tumour re..

Dependence receptors: new targets for cancer therapy

M Brisset, M Grandin, A Bernet, P Mehlen, F Hollande

2021-11-08

Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation wh..

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile

J Berthelet, VC Wimmer, HJ Whitfield, A Serrano, T Boudier, S Mangiola, M Merdas, F El-Saafin, D Baloyan, J Wilcox, S Wilcox, AC Parslow, AT Papenfuss, B Yeo, M Ernst, B Pal, RL Anderson, MJ Davis, KL Rogers, F Hollande

2021-07-01

Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in ..

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

AC Chüeh, G Advani, M Foroutan, J Smith, N Ng, H Nandurkar, DS Lio, HJ Zhu, YP Chong, H Verkade, DJ Fujita, J Bjorge, F Basheer, JP Lim, I Luk, A Dhillon, A Sakthianandeswaren, D Mouradov, O Sieber, F Hollande

2021-04-29

Hyperactivation of SRC-family protein kinases (SFKs) contributes to the initiation and progression of human colorectal cancer (CRC..

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

S Ceder, SE Eriksson, EH Cheteh, S Dawar, M Corrales Benitez, VJN Bykov, KM Fujihara, M Grandin, X Li, S Ramm, C Behrenbruch, KJ Simpson, F Hollande, L Abrahmsen, NJ Clemons, KG Wiman

2021-02-05

The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. The compound APR-246 (PRIMA-1Met/Eprenetapopt) is co..

Progastrin production transitions from Bmi1 /Prox1 to Lgr5high cells during early intestinal tumorigenesis

J Giraud, M Foroutan, J Boubaker-Vitre, F Grillet, Z Homayed, U Jadhav, P Crespy, C Breuker, JF Bourgaux, J Hazerbroucq, C Pignodel, B Brulin, RA Shivdasani, P Jay, F Hollande, J Pannequin

2021-02-01

Progastrin is an unprocessed soluble peptide precursor with a well-described tumor-promoting role in colorectal cancer. It is expr..

Impact of tumor and immunological heterogeneity on the anti-cancer immune response

C Shembrey, ND Huntington, F Hollande

2019-09-01

Metastatic tumors are the primary cause of cancer-related mortality. In recent years, interest in the immunologic control of malig..

A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients

J Cursons, F Souza-Fonseca-Guimaraes, M Foroutan, A Anderson, F Hollande, S Hediyeh-Zadeh, A Behren, ND Huntington, MJ Davis

2019-01-01

Natural killer (NK) cell activity is essential for initiating (TCGA), we show that patients with metastatic cutaneous antitumor re..

Optical barcoding highlights novel characteristics of treatment resistant cells in metastatic colorectal cancer

Frederic Hollande, Corina Behrenbruch, Carolyn Shembrey, Pu Xue Qiao, Davide Ferrari, Benjamin Thomson, Michael Michael, Alexander Heriot

2018-11-01

Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process

C Behrenbruch, C Shembrey, S Paquet-Fifield, C Mølck, HJ Cho, M Michael, BNJ Thomson, AG Heriot, F Hollande

2018-04-01

Surgery remains the curative treatment modality for colorectal cancer in all stages, including stage IV with resectable liver meta..

A spatio-temporal model and inference tools for longitudinal count data on multicolor cell growth

P Qiao, C Mølck, D Ferrari, F Hollande

2018-01-01

Multicolor cell spatio-temporal image data have become important to investigate organ development and regeneration, malignant grow..